Associations of neuropsychiatric symptoms with cognitive impairment: The utility of the mild behavioral impairment checklist and the neuropsychiatric interview questionnaire in a cognitive neurology clinic population

Abstract Background Mild Behavioral Impairment is characterized by later life emergent and persistent neuropsychiatric symptoms (NPS). MBI domains include impaired drive/motivation, affective dysregulation, impulse dyscontrol, social inappropriateness, psychosis. We aimed to compare the relationship between NPS cognition in patients with subjective cognitive decline (SCD), mild impairment (MCI) dementia, using Impairment‐Checklist (MBI‐C) Neuropsychiatric Inventory Questionnaire (NPI‐Q). were derived from NPI‐Q a published algorithm. Method Data was examined 1238 PROMPT Cognitive Neurology Clinic registry at University of Calgary. baseline MBI‐C (n=474) (n=1040). Forward stepwise linear regression models conducted total domain scores as assessed Montreal Assessment (MoCA). Age, diagnosis, sex education included covariates. Result Overall, 90% had an score>0 55.91% scored above cutoff (>7). prevalence (based on cutoff) 37% SCD, 54% MCI, 62% dementia cutoff. By domain, over half drive/motivation (59.57%), dysregulation (68.66%) or dyscontrol (64.11%), while relatively fewer inappropriateness (33.97%) psychotic (22.25%). For NPI‐Q, 67.98% including 60.36% 60.00% MCI 74.95% dementia. (61%) (58.50%) less than (44.31%), (23.19%) psychosis (10.18%). With increasing diagnostic severity, age, increased, MoCA decreased. Greater significantly associated lower score. Of all domains, strongest association both measures. diagnosis modifiers for MBI‐C. Conclusion are poorer regardless status. more strongly scores. These findings suggest that has utility capturing this specialty clinic population, complement NPI‐Q.